Joyoni Dey

Associate Professor

Ph.D. in Electrical and Computer Engineering, 1999 - Carnegie Mellon University

Louisiana State University
Department of Physics & Astronomy
459-A Nicholson Hall, Tower Dr.
Baton Rouge, LA 70803-4001
225-578-4289-Office
225-578-9048-Lab
deyj@lsu.edu

Teaching

• Fall: MedP 7111: Advanced Medical Imaging Physics
• Spring: MedP 4111: Introduction to Medical Imaging
• Spring: (Co-Instructor): Radiological Physics for Residents (LSU Health Sc)

Research Grants

• NIH NIBIB Trail-blazer Award 1-R21-EB029026-01A1 (PI: Dey, J)  Breast Cancer Detection and Imaging using Analyzer-less X-ray Interferometry, July 2020 - March 2023 (~3 years), Direct: $400K, Total: $524,584
• NSF EPSCOR RII Track 4 (PI: Dey, J)  Neutron Imaging Interferometry for Non-Destructive Testing, Feb 2020 - Jan 2021 (2 years), Direct: $155,262, Total: $227,680.  Award # 1929150 

Patents

• J. Dey and S.J. Glick, "SPECT Camera Design", Patent No., US 8,519,351 B2, Aug 27, 2013. 
• J. Dey, N. Bhusal, L. Butler, J. P. Dowling, K. Ham, V. Singh, "Phase Contrast X-ray Interferometry" US Patent No., 10872708 , Dec 22, 2020.
• J. Dey, N. Bhusal, L. Butler, J. Dowling, K. Ham and V. Singh, Patent No. US 11,488,740 B2, Nov 1, 2022. 

Students

Ph.D.

• Jingzhu Xu  (Graduated, May 2020). Received Coates Research Scholar Award, 2019, Physics & Astronomy for her dissertation topic, $5000.
• Hunter Meyer (Current, MSc/PhD)

MSc

• Lacey Medlock  (Graduation, Fall 2023)
• Bryce Smith (Graduated, Summer 2023)
• Sydney Carr (Graduated, Summer 2023)
• Ivan Hidrovo (Graduated, Summer 2022)
• Elizabeth Park (Graduated, Summer 2022)
• Hanif Soysal (Graduated, Summer 2019)
• Narayan Bhusal (Graduated, December 2018)  

Undergraduate

• Bryce Smith (2019-2020, Summer 2020)
• Ivan Hidrovo (2016, 2017, 2018 )
• Megan Chesal 2016, 2017, 2018)
• David Sanchez (REU, Summer 2017)

Research

• Research Interest in Medical Imaging, Image Processing and Deep Learning: Interferometric Imaging, Imaging system design and optimization reducing patient dose, imaging time; Image reconstruction with physical modeling; Deep-learning for oncological prediction and staging; Mathematical (pde) models of tumor growth and treatment; Segmentation and registration. My research focuses on new systems and algorithms designed to help large patient populations with new imaging advances: for example, new methods of imaging, higher resolution and sensitivity systems for lowering the dose to patients, better quality diagnostic images, more efficient acquisition etc.; pathological quantification algorithms; predictions for oncology; correction of motion artifacts for better diagnosis.

Current Projects Include

Interferometry

• Neutron Interferometry: Neutrons show wave-particle duality. They manifest interference effects similar to X-rays and visible light.  We wish to analyze and maximize the neutron interferometric beamline performance with simulations, theory and experiments. We investigated a Modulated Phase Grating interferometry system that requires a single phase grating with modulating structures to provide interference patterns at the detector. No analyzer grating or dual-phase gratings are needed. Neutrons interact relatively weakly with metal compared to X-rays. This is useful for imaging bone-metal joints, where X-ray imaging would lead to strong metal artifacts. The research team will perform biomedical imaging, such as non-invasive ex-vivo imaging of bone-implant interface, with scientist at the NIST Center for Neutron Research, Gaithersburg, MD.

Example Relevant Publications/Patents/Disclosures 

• I. Hidrovo*, J. Dey, H. Meyer*, D. S. Hussey, N. N. Klimov, L. Butler, K. Ham, W. D. Newhauser, “Neutron Interferometry using a Single Modulated Phase Grating”, Rev. Sci. Instrum. vol. 94, 045110, (2023), Published Online: 17 April 2023. Pre-print.
• Phase-Contrast X-ray interferometry not only provides attenuation images provided by conventional CT but also scatter and phase images, affording higher soft-tissue contrast in images compared to conventional CT. We are investigating a novel modulated phase grating (MPG) system to bring Phase Contrast X-ray a step closer to the clinic. In collaboration with Professor Les Butler (Dept of Chemistry, LSU), Dr. Kyungmin Ham (CAMD, LSU).

Example Relevant Publications/Patents/Disclosures

• J. Xu, K. Ham, J. Dey, “X-ray Interferometry without Analyzer for Breast CT Application, a Simulation Study”, J. of Medical Imaging, vol. 7, no. 2, 023503 (2020), doi:10.1117/1.JMI.7.2.023503 (open-access).
• J. Dey, N. Bhusal, L. Butler, J. P. Dowling, K. Ham, V. Singh, "Phase Contrast X-ray Interferometry" US Patent No., 10872708 , Dec 22, 2020

System Design and Optimization

• Optimizing a Novel Gamma Camera design for Cardiac SPECT: We are investigating a high-sensitive and/or high-resolution gamma-camera design with a system of Ellipsoid detectors with pinhole collimation for Cardiac SPECT, which is an important modality for assessing myocardial perfusion with millions of patients undergoing nuclear cardiology scans per year. In course of our research, we have built a comprehensive multi-pinhole system simulator and iterative reconstruction.

Example Relevant Publications/Patents/Disclosures

• J. Dey and S.J. Glick, "SPECT Camera Design", Patent No., US 8,519,351 B2, Aug 27, 2013.
• J. Dey, “Improvement of Performance of Cardiac SPECT Camera using Curved Detectors With Pinholes”, IEEE Trans. Nuclear Science, vol.59,           no.2,pp.334-347, April 2012.
• Bhusal, N. , Dey, J. , Xu, J. , Kalluri, K. , Konik, A. , Mukherjee, J. M. and Pretorius, P. H., "Performance Analysis of a High‐Sensitivity Multi‐Pinhole  Cardiac SPECT System withHemi‐. Ellipsoid Detectors". Med. Phys. 46 (1), pp. 116-126, January 2019. 
• H. Soysal, J. Dey, W. P. Donahue, K. Matthews, “Scintillation Event Localization in Hemi-Ellipsoid Detector for SPECT, a simulation study using GEANT4 Monte-Carlo”, Journal of Instrumentation, vol. 17, 2022. 

Deep-learning applications to Imaging

• J. Dey, J. Xu, and B. Smith "Investigation of artifacts due to large-area grating defects and correction using short window Fourier transform and convolution neural networks for phase-contrast x-ray interferometry", Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113124Z (16 March 2020); https://doi.org/10.1117/12.2549409
• Convolution neural networks for lung-cancer prediction for large patient datasets (student Ivan Hidrovo senior thesis, April 2018).
• Staging preclinical SPECT/CT data using support vector machine using key radiomic features (student Megan Chesal honors thesis, April 2018).

Building Bioanalytical Tools using Mathematical Models

• Tumor progress and disease treatment monitoring by extracting biophysical-model-parameters from images: Oncology Imaging is performed using modalities including CT, MRI, FDG-PET, SPECT etc. Applying realistic mathematical models to serial-images of tumors extracts biologically relevant information from images, such as cell-motility, growth-rate etc. We are investigating a new mathematical Finite Element tumor-model where effects of the necrotic core are considered in addition to cell-motility, growth, apoptosis and migration. We also acquired 6 preclinical serial SPECT/CT datasets and fitted an existing ode compartmental volume model. In collaboration with J. M. Mathis, PhD, (Dept of Comparative Biomedical Sciences, School of Vet Medicine, LSU) and S. W. Walker, PhD (Dept of Mathematics, LSU).

Example Relevant Publications/Patents/Disclosures

• I. Hidrovo, J. Dey, M. E. Chesal, D. Shumilov, N. Bhusal and J. M. Mathis, "Experimental Method and Statistical Analysis to Fit Tumor Growth Model Using SPECT/CT Imaging: A Preclinical Study", Quant Imaging in Med and Surg,  vol. 7, no. 3, pp. 299-309, June 2017,doi: 10.21037/qims.2017.06.05
• J. Dey, S. W. Walker, J. M. Mathis, D. Shumilov, K. M. Kirby and Y. Luo, "Modeling and analysis of a physical tumor model including the effects of necrotic core," in Proc 2015 IEEE   Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), San Diego, CA, 2015, pp. 1-4.
• Fat-mass and Lean-Mass Growth Models: Mathematical modeling of fat-mass and lean-mass growth upon overfeeding different diets (collaboration with S. Heymsfield, MD, and L. M. Redman, PhD, from Pennington Biomedical Research Center).     

Example Relevant Publications/Patents/Disclosures

• D. Shumilov, S. B. Heymsfield, Leanne M. Redman, Steven R. Smith, George A. Bray, K. Kalluri, J. Dey, “New Compartment Model Analysis of Lean- Mass and Fat-Mass Growth with Overfeeding”, Nutrition, vol. 32, no. 5, pp. 590-600, May 2016.